Fluorine is a common element that is widely distributed in Earth’s crust and exists in the form of fluorides in a number of minerals, such as fluorspar, cryolite and fluorapatite.

Traces of fluorides are present in many waters, with higher concentrations often associated with groundwater. In some areas rich in fluoride-containing minerals, well water may contain up to about 10 mg of fluoride per liter, although much higher concentrations can be found.

Fluoride is widely used in dental preparations to combat dental caries, particularly in areas of high sugar intake. These can be in the form of tablets, mouthwashes, toothpaste, varnishes or gels for local application. In some countries, fluoride may also be added to table salt or drinking-water in order to provide protection against dental caries. The amounts added to drinking-water are such that final concentrations are usually between 0.5 and 1 mg/l. The fluoride in final water is always present as fluoride ions, whether from natural sources or from artificial fluoridation.

Fluoride may be an essential element for humans; however, essentiality has not been demonstrated unequivocally. Meanwhile, there is evidence of fluoride being a beneficial element with regard to the prevention of dental caries.

Elevated fluoride intakes can have more serious effects on skeletal tissues. Skeletal fluorosis (with adverse changes in bone structure) may be observed when drinking-water contains 3–6 mg of fluoride per liter, particularly with high water consumption.

Crippling skeletal fluorosis usually develops only where drinking-water contains over 10 mg of fluoride per liter.